Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836578 | 0.86 | CCNE1 (0.67) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835475 | 0.84 | SMN1; SMN2 (0.63) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835776 | 0.82 | CCNE1 (0.70) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835614 | 0.81 | CCNE1 (0.67) | CCNE1CDK2CDK5ALDH1A1SMN1; SMN2 | |
| SCHEMBL18456670 | 0.80 | AURKB (0.52) | CDK2MAPTSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL5836854 | 0.79 | CCNE1 (0.77) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835387 | 0.77 | CCNE1 (0.74) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5836044 | 0.75 | LMNA (0.67) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835922 | 0.75 | CCNE1 (1.00) | CCNE1CDK2CDK5LMNAALDH1A1 | |
| SCHEMBL5835509 | 0.75 | SMN1; SMN2 (0.61) | CCNE1CDK2CDK5LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |