Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835894 | 0.99 | NPC1 (0.63) | NPC1RAB9APOLBCCNE1CDK2 | |
| SCHEMBL5479988 | 0.88 | NPC1 (0.49) | NPC1RAB9APOLBCCNE1CDK2 | |
| SCHEMBL5835916 | 0.87 | SMN1; SMN2 (0.70) | NPC1RAB9APOLBCCNE1CDK2 | |
| SCHEMBL5837240 | 0.86 | SMN1; SMN2 (0.68) | NPC1RAB9APOLBCCNE1CDK2 | |
| SCHEMBL5835651 | 0.82 | SMN1; SMN2 (0.61) | NPC1RAB9ACCNE1CDK2CDK5 | |
| SCHEMBL2656417 | 0.81 | POLB (0.59) | NPC1RAB9APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5835819 | 0.80 | CDK2 (0.63) | RAB9ACCNE1CDK2CDK5SMN1; SMN2 | |
| SCHEMBL2657359 | 0.80 | POLB (0.61) | NPC1RAB9APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5835907 | 0.79 | CDK2 (0.61) | CCNE1CDK2CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5836043 | 0.79 | CDK2 (0.61) | CCNE1CDK2CDK5SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |