Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657359 | 0.83 | POLB (0.61) | POLBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5836009 | 0.81 | NPC1 (0.61) | POLBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5835894 | 0.80 | NPC1 (0.63) | POLBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL27481293 | 0.75 | POLB (0.97) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2655905 | 0.74 | POLB (1.00) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28562030 | 0.73 | FFAR2 (0.47) | NPC1RAB9ASMN1; SMN2GAAFFAR2 | |
| SCHEMBL999739 | 0.72 | FFAR2 (0.46) | NPC1RAB9ASMN1; SMN2GAAFFAR2 | |
| SCHEMBL5479988 | 0.71 | NPC1 (0.49) | POLBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6225612 | 0.70 | NPC1 (0.76) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1948582 | 0.70 | ALDH1A1 (0.64) | POLBNPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | disclosed |