Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749230 | 0.98 | TDP1 (0.46) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL21052798 | 0.98 | TDP1 (0.46) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL5748773 | 0.98 | TDP1 (0.46) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL5745373 | 0.98 | TDP1 (0.46) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL4328588 | 0.93 | L3MBTL1 (0.39) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL1758510 | 0.83 | — | — | |
| SCHEMBL7723534 | 0.81 | RARB (0.51) | PTGS2CYP3A4ESR1ADRA2AADORA3 | |
| SCHEMBL534479 | 0.75 | L3MBTL1 (0.50) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL4177303 | 0.74 | TDP1 (0.59) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL1335859 | 0.74 | TDP1 (0.49) | TDP1L3MBTL1PTGS2CYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049317-B2 | CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC (US) | 2006-05-23 | — | — | US | claimed |
| EP-1427696-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-16 | — | — | EP | claimed |
| US-20030119885-A1 | CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC | 2003-06-26 | — | — | US | claimed |
| WO-2003022799-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-20 | — | — | WO | claimed |
| EP-1427696-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022799-A1 | CCR-3 RECEPTOR ANTAGONISTS V | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-20 | — | — | WO | disclosed |
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119885-A1 | CCR-3 receptor antagonists | CCR1, CCR3, CCR4 | TDP1 4319/4885L3MBTL1 2590/4885PTGS2 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.