Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | GAA | P10253 | 9/20 | 0.42 |
| ▸ | HPGD | P15428 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17903393 | 0.90 | MAPT (0.51) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL15236872 | 0.85 | ALDH1A1 (0.41) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5837919 | 0.84 | ADORA1 (0.37) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5838672 | 0.80 | ADORA1 (0.38) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5838350 | 0.80 | ADORA1 (0.38) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL21597587 | 0.79 | ALDH1A1 (0.48) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5838071 | 0.76 | GRM6 (0.41) | ADORA1ALDH1A1MAPTGAATSHR | |
| SCHEMBL5837719 | 0.76 | ADORA1 (0.36) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5842462 | 0.76 | ADORA1 (0.36) | ADORA1ALDH1A1MAPTGAAHPGD | |
| SCHEMBL5838406 | 0.76 | GRM6 (0.40) | ADORA1ALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |