Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490599 | 0.88 | ADORA1 (0.39) | ADORA1MAPTKEAP1NFE2L2KDM4E | |
| SCHEMBL5838518 | 0.86 | CXCR2 (0.36) | UCHL1MAPTKMT2AMEN1KEAP1 | |
| SCHEMBL5837464 | 0.84 | ADORA1 (0.35) | GRM6ADORA1MAPTKMT2AMEN1 | |
| SCHEMBL5771556 | 0.83 | MAPT (0.38) | ADORA1MAPTKMT2AMEN1LMNA | |
| SCHEMBL5837716 | 0.81 | GRM6 (0.38) | GRM6UCHL1ADORA1MAPTKMT2A | |
| SCHEMBL5838078 | 0.81 | GRM6 (0.36) | GRM6UCHL1ADORA1MAPTKMT2A | |
| SCHEMBL5838372 | 0.75 | GRM6 (0.37) | GRM6ADORA1MAPTKMT2AMEN1 | |
| SCHEMBL5838317 | 0.75 | CXCR2 (0.33) | MAPTKMT2AGAANT5ECXCR2 | |
| SCHEMBL5837554 | 0.72 | ADORA1 (0.40) | GRM6ADORA1MAPTKEAP1NFE2L2 | |
| SCHEMBL5838395 | 0.72 | GRM6 (0.36) | GRM6ADORA1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |