Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 13/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837455 | 0.87 | GHSR (0.38) | ADORA1KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5837175 | 0.86 | TPSAB1 (0.39) | ADORA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5768500 | 0.84 | GRM6 (0.37) | ADORA1KEAP1NFE2L2GRM6MAPT | |
| SCHEMBL5769847 | 0.84 | GRM6 (0.37) | ADORA1KEAP1NFE2L2GRM6MAPT | |
| SCHEMBL5768503 | 0.84 | GRM6 (0.37) | ADORA1KEAP1NFE2L2GRM6MAPT | |
| SCHEMBL5771550 | 0.82 | CASP3 (0.39) | ADORA1KDM4EMAPT | |
| SCHEMBL5838074 | 0.80 | GRM6 (0.39) | ADORA1GRM6KDM4EMAPTALDH1A1 | |
| SCHEMBL5837710 | 0.79 | ADORA1 (0.43) | ADORA1GRM6KDM4EMAPT | |
| SCHEMBL6049995 | 0.79 | ADORA1 (0.43) | ADORA1GRM6KDM4EMAPT | |
| SCHEMBL7490590 | 0.79 | KEAP1 (0.45) | ADORA1KEAP1NFE2L2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |