Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 17/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 9/20 | 0.48 |
| ▸ | PTPRB | P23467 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | PTPRE | P23469 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837572 | 1.00 | PTPN1 (0.53) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL5837812 | 0.84 | HPGD (0.45) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL7574709 | 0.84 | PTPN1 (0.41) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL6050042 | 0.84 | PTPN1 (0.41) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL5838458 | 0.80 | PTPN1 (0.55) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL5838274 | 0.77 | PTPN1 (0.45) | PTPN1PTPN2PTPRBPTPRCNPC1 | |
| SCHEMBL7519532 | 0.77 | PTPN1 (0.47) | PTPN1PTPN2PTPRBKDM4EHPGD | |
| SCHEMBL5836756 | 0.75 | PTPN1 (0.45) | PTPN1PTPN2PTPRBPTPRCPTPRA | |
| SCHEMBL5838486 | 0.75 | PTPN1 (0.45) | PTPN1PTPN2PTPRBPTPRCPTPRA | |
| SCHEMBL7522183 | 0.74 | PTPN1 (0.46) | PTPN1PTPN2PTPRBHPGDPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | claimed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | claimed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | claimed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |