Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 20/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 14/20 | 0.54 |
| ▸ | PTPRB | P23467 | 2/20 | 0.54 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPRE | P23469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843149 | 0.79 | PTPN1 (0.55) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5838411 | 0.78 | PTPN1 (0.57) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL6208795 | 0.76 | PTPN1 (0.59) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5838480 | 0.75 | PTPN1 (0.62) | PTPN1PTPN2PTPRBPTPRCPTPRE | |
| SCHEMBL5837532 | 0.74 | PTPN1 (0.51) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5837036 | 0.74 | PTPN1 (0.55) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5837671 | 0.74 | PTPN1 (0.49) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5837494 | 0.73 | PTPN1 (0.49) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5837045 | 0.71 | PTPN1 (0.52) | PTPN1PTPN2PTPRBPTPRAPTPRC | |
| SCHEMBL5838663 | 0.71 | PTPN1 (0.47) | PTPN1PTPN2PTPRBPTPRAPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |