Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837576 | 0.87 | KDM4E (0.42) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5838238 | 0.77 | PTPN1 (0.40) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL18919114 | 0.65 | ALDH1A1 (0.65) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5110673 | 0.64 | ALDH1A1 (0.61) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL17447387 | 0.63 | ALDH1A1 (0.54) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL18889776 | 0.62 | ALDH1A1 (0.56) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL4720481 | 0.62 | GAA (0.71) | KDM4ENPC1RAB9AALDH1A1GAA | |
| SCHEMBL27622272 | 0.62 | ALDH1A1 (0.57) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8877563 | 0.62 | ALDH1A1 (0.67) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL7344801 | 0.61 | ALDH1A1 (0.67) | KDM4ENPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |