Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049849 | 1.00 | NT5E (0.38) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL6049867 | 0.90 | NT5E (0.37) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL5837084 | 0.90 | NT5E (0.37) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL5837758 | 0.83 | CXCR2 (0.42) | NT5ECXCR2L3MBTL1PDE4DNPSR1 | |
| SCHEMBL6049954 | 0.83 | CXCR2 (0.42) | NT5ECXCR2L3MBTL1PDE4DNPSR1 | |
| Hydrochloric Acid SCHEMBL6049951 | 0.82 | CXCR2 (0.41) | NT5ECXCR2L3MBTL1NPSR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5837753 | 0.82 | CXCR2 (0.41) | NT5ECXCR2L3MBTL1NPSR1CYP3A4 | |
| SCHEMBL5837710 | 0.81 | ADORA1 (0.43) | KMT2A | |
| SCHEMBL6049995 | 0.81 | ADORA1 (0.43) | KMT2A | |
| SCHEMBL5838339 | 0.79 | NT5E (0.37) | NT5ECXCR2L3MBTL1ADORA3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |