Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837092 | 0.89 | PREP (0.41) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL5838449 | 0.87 | CXCR2 (0.39) | NT5ECXCR2L3MBTL1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5837761 | 0.85 | CXCR2 (0.39) | NT5ECXCR2CASP1L3MBTL1ALDH1A1 | |
| SCHEMBL5837716 | 0.82 | GRM6 (0.38) | CXCR2MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6049867 | 0.82 | NT5E (0.37) | NT5ECXCR2CASP1L3MBTL1ADORA3 | |
| SCHEMBL5837084 | 0.82 | NT5E (0.37) | NT5ECXCR2CASP1L3MBTL1ADORA3 | |
| SCHEMBL5838102 | 0.81 | PTPN1 (0.38) | NT5ECXCR2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL6049849 | 0.79 | NT5E (0.38) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL5838331 | 0.79 | NT5E (0.38) | NT5ECXCR2L3MBTL1ADORA3PDE4D | |
| SCHEMBL5838939 | 0.77 | CXCR2 (0.36) | NT5ECXCR2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |