Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.48 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.38 |
| ▸ | RAB7A | P51149 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838353 | 0.85 | ADORA1 (0.41) | CXCR2TSPOGRM6ADORA1ALDH1A1 | |
| SCHEMBL5838158 | 0.85 | CXCR2 (0.54) | CXCR2TSPOCXCR4RAB7AALDH1A1 | |
| SCHEMBL5838598 | 0.84 | ALDH1A1 (0.41) | CXCR2GRM6ADORA1ALDH1A1GAA | |
| SCHEMBL6316682 | 0.79 | GRM6 (0.40) | CXCR2TSPOGRM6ADORA1ALDH1A1 | |
| SCHEMBL5838302 | 0.78 | HDAC8 (0.49) | CXCR2TSPOGRM6CXCR4ADORA1 | |
| SCHEMBL5838763 | 0.76 | ADORA1 (0.47) | GRM6ADORA1ALDH1A1GAAMAPT | |
| SCHEMBL15832909 | 0.76 | ALDH1A1 (0.42) | CXCR2TSPOGRM6CISD2RAB7A | |
| SCHEMBL6316717 | 0.75 | GRM6 (0.43) | CXCR2GRM6RAB7AADORA1ALDH1A1 | |
| SCHEMBL5838372 | 0.75 | GRM6 (0.37) | CXCR2TSPOGRM6ADORA1ALDH1A1 | |
| SCHEMBL5837176 | 0.73 | PTPN1 (0.50) | RAB7AALDH1A1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |