Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 7/20 | 0.49 |
| ▸ | GABRD | O14764 | 7/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.49 |
| ▸ | GABRE | P78334 | 7/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.49 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.49 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.49 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524872 | 0.82 | MAPT (0.42) | MAPTMEN1KMT2A | |
| SCHEMBL7528917 | 0.78 | KDM4E (0.46) | MAPTMEN1POLBKMT2A | |
| SCHEMBL5837057 | 0.78 | KDM4E (0.46) | MAPTMEN1POLBKMT2A | |
| SCHEMBL7523468 | 0.78 | NT5E (0.37) | MAPTMEN1POLBKMT2A | |
| SCHEMBL5837595 | 0.77 | KDM4E (0.39) | MAPTMEN1KMT2A | |
| SCHEMBL5838311 | 0.77 | AKR1C2 (0.39) | MAPT | |
| SCHEMBL5838322 | 0.76 | MAPT (0.37) | TP53ALOX5MAPTMEN1KMT2A | |
| SCHEMBL7517807 | 0.75 | KDM4E (0.38) | MAPT | |
| SCHEMBL5772973 | 0.75 | MAPT (0.41) | MAPTMEN1KMT2A | |
| SCHEMBL5838533 | 0.74 | ALDH1A1 (0.46) | TP53MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |