SCHEMBL5838729

SCHEMBL5838729

C=CC(=O)OCCC(O[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)[SiH](O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.37
HPGD P15428 1/20 0.37
ALDH1A1 P00352 4/20 0.37
TP53 P04637 3/20 0.37
HIF1A Q16665 3/20 0.37
CYP3A4 P08684 2/20 0.37
HSD17B10 Q99714 1/20 0.37
THRB P10828 2/20 0.33
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5839203 0.78 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL374777 0.74 TSHR (0.43) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3419812 0.73 TSHR (0.50) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL5606170 0.71
SCHEMBL9302811 0.69 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL9303062 0.69 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL22191456 0.69 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL9303920 0.69 TSHR (0.46) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL13966307 0.68 TSHR (0.50) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL28521074 0.68 TSHR (0.50) TSHRHPGDALDH1A1TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866531-B2 Oil-resistant lens material and ophthalmic devices Twenty Twenty Therapeutrics LLC (US) 2024-01-09 US disclosed
WO-2021067189-A1 OIL-RESISTANT LENS MATERIAL AND ELECTROWETTING OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC (US) 2021-04-08 WO disclosed
US-20210095063-A1 OIL-RESISTANT LENS MATERIAL AND OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC 2021-04-01 US disclosed
US-10752833-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2020-08-25 US disclosed
US-20190194535-A1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORPORATION (JP) 2019-06-27 US disclosed
US-10119070-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2018-11-06 US disclosed
US-9885883-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2018-02-06 US disclosed
US-20170088771-A1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORPORATION (JP) 2017-03-30 US disclosed
EP-2951620-B1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORP (JP) 2017-03-01 EP disclosed
US-9574067-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2017-02-21 US disclosed
US-20040039077-A1 Ocular lens material MENICON CO., LTD. 2004-02-26 US disclosed
US-6638991-B2 Lens material comprising a copolymer derived from a polysiloxane endcapped with acrylated urethane groups, a silicon-containing alkyl methacrylate, a hydrophilic monomer, and a crosslinking monomer; oxygen permeability, strength MENICON CO., LTD. (JP) 2003-10-28 US disclosed
US-20020198280-A1 Material for ocular lens MENICON CO., LTD. (JP) 2002-12-26 US disclosed
EP-1197782-A1 MATERIAL FOR OCULAR LENS MENICON CO., LTD. (JP) 2002-04-17 EP disclosed
US-6255362-B1 HYDRATED, CROSSLINKED COPOLYACRYLATE CONTAINING SILOXANE, URETHANE AND ETHER GROUPS; CLEAR, DURABLE, FLEXIBLE SOFT CONTACT LENSES MENICON CO., LTD. (JP) 2001-07-03 US disclosed
EP-0937998-A2 Ocular lens material and process for producing the same Menicon Co., Ltd. (JP) 1999-08-25 EP disclosed
EP-0294515-B1 Contact lens material MENICON CO LTD (JP) 1994-05-25 EP disclosed
US-4814402-A VINYLPYRROLIDONE OR METHACRYLIC ACID AND SILICON CONTAINING METHACRYLATE MENICON CO., LTD. (JP) 1989-03-21 US disclosed
US-4594401-A Oxygen permeable hard contact lens formed from styrene monomer containing a silyl or siloxane group SHIN-ETSU CHEMICAL CO., LTD. (JP) 1986-06-10 US disclosed
US-4433125-A COPOLYMER OF SILICON CONTAINING ACRYLATE OR METHACRYLATE, AND FLUOROALKYL ACRYLATE OR METHACRYLATE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1984-02-21 US disclosed