Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458863 | 0.82 | ERBB2 (0.60) | EGFRKDRSUV39H1AURKAERBB2 | |
| SCHEMBL5840485 | 0.80 | PDGFRB (0.58) | PDGFRBFLT4MEN1KMT2AEGFR | |
| SCHEMBL4472351 | 0.77 | ERBB2 (0.71) | EGFRKDRSUV39H1ERBB2 | |
| SCHEMBL8809879 | 0.76 | EGFR (0.82) | MEN1KMT2AEGFRHTTKDM4E | |
| SCHEMBL8737039 | 0.75 | DRD4 (0.64) | KMT2ALMNADRD4 | |
| SCHEMBL618488 | 0.73 | RAF1 (0.61) | LMNAHPGDDRD4 | |
| SCHEMBL5839290 | 0.72 | MEN1 (0.62) | PDGFRBFLT4MEN1KMT2AEGFR | |
| SCHEMBL6181626 | 0.71 | MEN1 (1.00) | MEN1KMT2AEGFRHTTKDM4E | |
| SCHEMBL5824969 | 0.71 | PDGFRA (0.73) | FLT4KDRPDGFRAFLT1 | |
| SCHEMBL20782507 | 0.71 | HTT (0.69) | MEN1KMT2AEGFRKDRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636195-A1 | QUINAZOLINES AND PYRIDO[3,4-D]PYRIMIDINES AS RECEPTOR TYROSINE KINASE INHIBITORS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004106308-A1 | QUINAZOLINES AND PYRIDO [3,4-D] PYRIMIDINES AS RECEPTOR TYROSINE KINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |