Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839290 | 0.92 | MEN1 (0.62) | PDGFRBFLT4MEN1KMT2AHTT | |
| SCHEMBL4460760 | 0.81 | ERBB2 (0.65) | EGFRERBB2KDR | |
| SCHEMBL8809879 | 0.80 | EGFR (0.82) | MEN1KMT2AHTTEGFRKDM4E | |
| SCHEMBL5839239 | 0.80 | PDGFRB (0.58) | PDGFRBFLT4MEN1KMT2AHTT | |
| SCHEMBL6181626 | 0.75 | MEN1 (1.00) | MEN1KMT2AHTTEGFRKDM4E | |
| SCHEMBL20782507 | 0.74 | HTT (0.69) | MEN1KMT2AHTTEGFRKDM4E | |
| SCHEMBL4463533 | 0.74 | ERBB2 (0.78) | EGFRERBB2KDR | |
| SCHEMBL22291162 | 0.74 | MEN1 (0.75) | MEN1KMT2AHTTEGFRKDM4E | |
| SCHEMBL13702268 | 0.73 | NPSR1 (0.61) | LMNAALDH1A1HDAC8 | |
| SCHEMBL6179448 | 0.72 | EGFR (1.00) | MEN1KMT2AHTTEGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636195-A1 | QUINAZOLINES AND PYRIDO[3,4-D]PYRIMIDINES AS RECEPTOR TYROSINE KINASE INHIBITORS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004106308-A1 | QUINAZOLINES AND PYRIDO [3,4-D] PYRIMIDINES AS RECEPTOR TYROSINE KINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |