⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014096 | 1.00 | — | — | |
| SCHEMBL1189342 | 1.00 | — | — | |
| SCHEMBL8890971 | 1.00 | — | — | |
| SCHEMBL20088936 | 0.82 | TSHR (0.35) | — | |
| SCHEMBL18160120 | 0.82 | TSHR (0.35) | — | |
| SCHEMBL20088929 | 0.82 | TSHR (0.35) | — | |
| SCHEMBL1784659 | 0.80 | PTPN1 (0.39) | — | |
| SCHEMBL5499760 | 0.80 | TSHR (0.33) | — | |
| SCHEMBL5494816 | 0.80 | TSHR (0.33) | — | |
| SCHEMBL13176735 | 0.80 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165640-A1 | FRUCTOSE-6-PHOSPHATE ALDOLASE VARIANTS FOR ALDOL CARBOLIGATIONS | SUSTAINABLE MOMENTUM, S.L. (ES) | 2020-05-28 | — | — | US | disclosed |
| CN-110945122-A | Fructose-6-phosphate aldolase variants for aldol condensation carbon linking | 西班牙高等科研理事会 | 2020-03-31 | — | — | CN | disclosed |
| EP-3610011-A1 | FRUCTOSE-6-PHOSPHATE ALDOLASE VARIANTS FOR ALDOL CARBOLIGATIONS | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018189026-A1 | FRUCTOSE-6-PHOSPHATE ALDOLASE VARIANTS FOR ALDOL CARBOLIGATIONS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2018-10-18 | — | — | WO | disclosed |
| EP-3388518-A1 | FRUCTOSE-6-PHOSPHATE ALDOLASE VARIANTS FOR ALDOL CARBOLIGATIONS | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2018-10-17 | — | — | EP | disclosed |
| US-7101684-B2 | Modified modular polyketide synthase | STANFORD UNIVERSITY (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1493814-A1 | Cell-free synthesis of polyketides | THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0836649-B1 | CELL-FREE SYNTHESIS OF POLYKETIDES | UNIV LELAND STANFORD JUNIOR (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040203119-A1 | Cell-free synthesis of polyketides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-10-14 | — | — | US | disclosed |
| US-6750040-B1 | BY INCUBATING APPROPRIATE SUBSTRATE SET; FOR MAKING A LIBRARY OF POLYKETIDES | BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2004-06-15 | — | — | US | disclosed |
| US-6274560-B1 | INCUBATING DIKETIDE WITH MODIFIED POLYKETIDE SYNTHASE; RECOVERING; GENETIC ENGINEERING | BROWN UNIVERSITY RESEARCH FOUNDATION | 2001-08-14 | — | — | US | disclosed |
| US-6080555-A | Synthesis of polyketides from diketides | STANFORD UNIVERSITY (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0836649-A4 | CELL-FREE SYNTHESIS OF POLYKETIDES | UNIV LELAND STANFORD JUNIOR (US) | 2000-04-05 | — | — | EP | disclosed |
| EP-0836649-A1 | CELL-FREE SYNTHESIS OF POLYKETIDES | THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002358-A1 | CELL-FREE SYNTHESIS OF POLYKETIDES | THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1997-01-23 | — | — | WO | disclosed |