Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CDC20 | Q12834 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218212 | 0.82 | ACVR1 (0.51) | YTHDC1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL5840019 | 0.77 | CDK2 (0.52) | CDK2CCNE2CCNE1CDK1CCNA2 | |
| SCHEMBL21967621 | 0.77 | YTHDC1 (0.61) | YTHDC1KMT2AADORA3ADORA1 | |
| SCHEMBL183098 | 0.77 | YTHDC1 (0.64) | YTHDC1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL183230 | 0.77 | CDK1 (0.66) | YTHDC1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL21967158 | 0.77 | YTHDC1 (0.66) | YTHDC1ADORA3ADORA1 | |
| SCHEMBL183231 | 0.76 | CDK2 (0.70) | YTHDC1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL5841016 | 0.75 | BRAF (0.52) | CDK2ADORA3ADORA1 | |
| SCHEMBL183282 | 0.74 | YTHDC1 (0.61) | YTHDC1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL183397 | 0.74 | YTHDC1 (0.61) | YTHDC1CDK2CCNE2CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |