Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 9/20 | 0.62 |
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.47 |
| ▸ | CDK2 | P24941 | 7/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840603 | 1.00 | CDK1 (0.62) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL7110928 | 0.84 | CSNK2A1 (0.47) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL7110933 | 0.84 | CSNK2A1 (0.47) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL4900930 | 0.82 | FLT3 (0.48) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL4900939 | 0.82 | FLT3 (0.48) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL4894170 | 0.81 | FLT3 (0.60) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL4894184 | 0.81 | FLT3 (0.60) | CDK1PRKCAPAK4PDGFRACDK2 | |
| SCHEMBL4889926 | 0.79 | MAPKAPK2 (0.55) | CDK1PRKCAPDGFRACDK2CCNE1 | |
| SCHEMBL4889912 | 0.79 | MAPKAPK2 (0.55) | CDK1PRKCAPDGFRACDK2CCNE1 | |
| SCHEMBL4899218 | 0.78 | FLT3 (0.48) | CDK1PDGFRACDK2CCNE1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |