Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840980 | 1.00 | TACR1 (0.49) | TACR1MAOAKDM1AMAOBSLC6A4 | |
| SCHEMBL5840994 | 1.00 | TACR1 (0.49) | TACR1MAOAKDM1AMAOBSLC6A4 | |
| SCHEMBL4967825 | 0.89 | TACR1 (0.52) | TACR1SLC6A4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4005877 | 0.89 | TACR1 (0.52) | TACR1SLC6A4CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5840741 | 0.88 | TACR1 (0.51) | TACR1SLC6A4CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5840730 | 0.88 | TACR1 (0.51) | TACR1SLC6A4CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL4005504 | 0.88 | TACR1 (0.51) | TACR1SLC6A4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5839321 | 0.87 | TACR1 (0.52) | TACR1MAOBSLC6A4HTR2CHTR2B | |
| SCHEMBL5839307 | 0.87 | TACR1 (0.52) | TACR1MAOBSLC6A4HTR2CHTR2B | |
| SCHEMBL4964218 | 0.87 | TACR1 (0.52) | TACR1MAOBSLC6A4HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138423-B2 | Diseases mediated by tachykinins and for seritonin reuptake transporter protein as reuptake inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-11-21 | — | — | US | disclosed |
| US-20060020011-A1 | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists | BRISTOL-MEYERS SQUIBB COMPANY | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020011-A1 | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists | TPH1, SLC6A4, HTR1D | TACR1 24/4885MAOA 470/4885KDM1A 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.