Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842523 | 0.91 | ALDH1A1 (0.58) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5844742 | 0.90 | ALDH1A1 (0.67) | MAPTALDH1A1NPSR1GAASMN1; SMN2 | |
| SCHEMBL5841214 | 0.89 | MAPT (0.58) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5842942 | 0.87 | MAPT (0.53) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5842320 | 0.86 | SMN1; SMN2 (0.69) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5842951 | 0.86 | ALDH1A1 (0.61) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5842345 | 0.85 | NPSR1 (0.64) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL27617642 | 0.85 | POLB (0.60) | MAPTALDH1A1NPSR1USP2SMN1; SMN2 | |
| SCHEMBL5842555 | 0.83 | NPSR1 (0.61) | MAPTALDH1A1NPSR1USP2GAA | |
| SCHEMBL5842831 | 0.82 | MAPT (0.65) | MAPTALDH1A1NPSR1USP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |