Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.41 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.40 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.40 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5842845 | 1.00 | PTGER4 (0.42) | PTGER4TSHRHTTMEN1HRH3 | |
| SCHEMBL6983793 | 0.91 | HRH3 (0.47) | MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5842157 | 0.89 | KCNA5 (0.49) | PTGER4MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5842146 | 0.89 | KCNA5 (0.49) | PTGER4MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5841476 | 0.88 | HRH3 (0.53) | MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5841486 | 0.88 | HRH3 (0.53) | MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5841005 | 0.87 | TSHR (0.41) | PTGER4TSHRHTTMEN1HRH3 | |
| Fumaric Acid SCHEMBL5841010 | 0.87 | TSHR (0.41) | PTGER4TSHRHTTMEN1HRH3 | |
| Fumaric Acid SCHEMBL5841769 | 0.87 | HRH3 (0.53) | MEN1HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5841776 | 0.87 | HRH3 (0.53) | MEN1HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992085-B2 | Octahydro-2H-pyrido[1,2-a]pyrazine compounds | LES LABORATORIES SERVIER (FR) | 2006-01-31 | — | — | US | disclosed |
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | LES LABORATOIRES SERVIER (FR) | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | CYP2W1, OXER1, IL1R1 | MEN1 3131/4885HRH1 93/4885KCNH2 1810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.