Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841400 | 0.91 | ALDH1A1 (0.51) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 | |
| SCHEMBL5842938 | 0.90 | ALDH1A1 (0.51) | ALDH1A1MAPTNPSR1SMN1; SMN2KDM4E | |
| SCHEMBL5842946 | 0.88 | ALDH1A1 (0.62) | ALDH1A1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL5841000 | 0.86 | ALDH1A1 (0.55) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 | |
| SCHEMBL5842512 | 0.85 | ALDH1A1 (0.62) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 | |
| SCHEMBL5844738 | 0.84 | ALDH1A1 (0.73) | ALDH1A1MAPTLMNATP53POLB | |
| SCHEMBL5843367 | 0.83 | MAPT (0.62) | ALDH1A1MAPTNPSR1SMN1; SMN2KDM4E | |
| SCHEMBL5841634 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPTNPSR1SMN1; SMN2TP53 | |
| SCHEMBL5843205 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 | |
| SCHEMBL5841403 | 0.83 | MAPT (0.51) | ALDH1A1MAPTNPSR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | claimed |
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | ALDH1A1 3034/4885MAPT 4395/4885NPSR1 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.