Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155796 | 0.88 | PTPN2 (0.43) | ALDH1A1GAAKDM4EPTPN2PTPN1 | |
| SCHEMBL5837083 | 0.86 | PTPN1 (0.49) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL7563366 | 0.82 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL7538674 | 0.82 | CA9 (0.45) | ALDH1A1NPC1RAB9AKDM4EPOLB | |
| SCHEMBL7565443 | 0.81 | PTPN2 (0.38) | ALDH1A1GAAKDM4EPTPN2PTPN1 | |
| SCHEMBL7562697 | 0.78 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL7539939 | 0.78 | GAA (0.41) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL7536578 | 0.75 | PTPN1 (0.38) | PTPN2PTPN1PTPRB | |
| SCHEMBL7534087 | 0.73 | MEN1 (0.38) | ALDH1A1NPC1KDM4EPTPN2PTPN1 | |
| SCHEMBL6394168 | 0.73 | PTPN1 (0.36) | PTPN2PTPN1PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |