Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843865 | 0.91 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL5843404 | 0.90 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2TDP1CA12CA1 | |
| SCHEMBL5842752 | 0.85 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2TDP1MAPTLMNA | |
| SCHEMBL5841897 | 0.85 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5844508 | 0.82 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL5841595 | 0.82 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5843238 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL5842760 | 0.82 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5841930 | 0.82 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL5842367 | 0.82 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2TDP1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | ALDH1A1 3034/4885SMN1; SMN2 3678/4885TDP1 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.