Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.34 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL5844202 | 1.00 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL10977701 | 0.97 | NAPRT (0.60) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL179840 | 0.97 | NAPRT (0.60) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL11125163 | 0.97 | NAPRT (0.60) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL2064519 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL8582033 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL153596 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL11225938 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL10380397 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK | |
| Pyridine SCHEMBL9246176 | 0.94 | NAPRT (0.56) | NAPRTTSHRTDP1FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143858-A | 17 alpha-hydroxy progesterone preparation method | 江苏佳尔科药业集团股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-116143858-A | 17 alpha-hydroxy progesterone preparation method | 江苏佳尔科药业集团股份有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-7125492-B2 | Additives for reversed-phase HPLC mobile phases | AGILENT TECHNOLOGIES, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-20050011836-A1 | Additives for reversed-phase HPLC mobile phases | AGILENT TECHNOLOGIES, INC. | 2005-01-20 | — | — | US | disclosed |