Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 16/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.51 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846715 | 0.95 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5845095 | 0.93 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5845229 | 0.93 | ITGAV (0.50) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5846580 | 0.93 | ITGAV (0.50) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5845357 | 0.93 | ITGAV (0.50) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5844324 | 0.92 | ITGAV (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5844812 | 0.91 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5845989 | 0.91 | ITGAV (0.47) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| SCHEMBL5846038 | 0.90 | ITGAV (0.51) | ITGAVITGB3ITGB6ITGA2BITGB5 | |
| Trifluoroacetic Acid SCHEMBL5844722 | 0.89 | ITGAV (0.61) | ITGAVITGB3ITGB6ITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135587-B2 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2006-11-14 | — | — | US | disclosed |
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | ITGB1, ITGB2, ITGA1 | ITGAV 16/4885ITGB3 7/4885ITGB6 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.