Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.49 |
| ▸ | HTR2C | P28335 | 14/20 | 0.49 |
| ▸ | HTR2B | P41595 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845389 | 1.00 | HTR2A (0.49) | HTR2AHTR2CHTR2BMAPK1ATM | |
| SCHEMBL5638272 | 0.83 | HTR2A (0.46) | HTR2AHTR2CHTR2BMAPK1ATM | |
| SCHEMBL5638269 | 0.83 | HTR2A (0.46) | HTR2AHTR2CHTR2BMAPK1ATM | |
| SCHEMBL5845487 | 0.83 | HTR2A (0.46) | HTR2AHTR2CHTR2BMAPK1ATM | |
| SCHEMBL5843691 | 0.77 | HTR2C (0.55) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL5845010 | 0.77 | HTR2C (0.58) | HTR2AHTR2CHTR2BLMNAHTR1A | |
| SCHEMBL5843697 | 0.77 | HTR2C (0.55) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL5845013 | 0.77 | HTR2C (0.58) | HTR2AHTR2CHTR2BLMNAHTR1A | |
| SCHEMBL27140224 | 0.76 | ESR1 (0.39) | HTR2AHTR2CHTR2BESR1ESR2 | |
| SCHEMBL5844513 | 0.76 | HTR2C (0.51) | HTR2AHTR2CHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129257-B1 | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2006-10-31 | — | — | US | disclosed |