Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.46 |
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR2B | P41595 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5638272 | 1.00 | HTR2A (0.46) | HTR2AHTR2CHTR2BPOLBKMO | |
| SCHEMBL5638269 | 1.00 | HTR2A (0.46) | HTR2AHTR2CHTR2BPOLBKMO | |
| SCHEMBL5845398 | 0.83 | HTR2A (0.49) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL5845389 | 0.83 | HTR2A (0.49) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL5637628 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL5843663 | 0.81 | HTR2C (0.53) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL5843328 | 0.81 | HTR2A (0.50) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL4950336 | 0.81 | HTR2A (0.49) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL4948409 | 0.80 | HTR2A (0.48) | HTR2AHTR2CHTR2BKMOMAPK1 | |
| SCHEMBL5639490 | 0.78 | HTR2A (0.46) | HTR2AHTR2CHTR2BKMOHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129257-B1 | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma | ALCON, INC. (CH) | 2006-10-31 | — | — | US | disclosed |
| US-20060069096-A1 | Pyrazolo[3,4-e]benzoxazoles for the treatment of glaucoma | DANTANARAYANA ANURA P | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069096-A1 | Pyrazolo[3,4-e]benzoxazoles for the treatment of glaucoma | PTGIR, PDE3A, TBXA2R | HTR2A 3491/4885HTR2C 2389/4885HTR2B 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.