Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797092 | 0.93 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5844274 | 0.80 | CRHR1 (0.53) | CRHR1TP53KDM4EMEN1ALDH1A1 | |
| SCHEMBL5844163 | 0.79 | CRHR1 (0.52) | CRHR1TP53KDM4EMEN1ALDH1A1 | |
| SCHEMBL8804003 | 0.74 | CRHR1 (0.53) | CRHR1TP53KDM4EMEN1ALDH1A1 | |
| SCHEMBL6798917 | 0.73 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5845311 | 0.71 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5599818 | 0.71 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL7437676 | 0.71 | CRHR1 (0.45) | CRHR1KDM4EALDH1A1 | |
| SCHEMBL6304617 | 0.70 | CRHR1 (0.44) | CRHR1KDM4EALDH1A1 | |
| SCHEMBL7360292 | 0.70 | CRHR1 (0.70) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| EP-0764166-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER (US) | 2000-09-13 | — | — | EP | disclosed |
| WO-1995033750-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |