Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762169 | 0.89 | MCHR1 (0.38) | ROCK2MCHR1ELANE | |
| SCHEMBL5761733 | 0.86 | ELANE (0.37) | ROCK2MCHR1ELANE | |
| SCHEMBL5790143 | 0.84 | ROCK2 (0.39) | ROCK2P2RX3MCHR1 | |
| SCHEMBL5762922 | 0.84 | MCHR1 (0.47) | ROCK2MCHR1 | |
| SCHEMBL5762196 | 0.83 | CHRNA7 (0.39) | ROCK2P2RX3MCHR1ELANE | |
| SCHEMBL5166655 | 0.82 | ROCK2 (0.41) | POLBROCK2TP53LMNARXFP1 | |
| SCHEMBL5760136 | 0.81 | ROCK2 (0.51) | ROCK2LMNAMCHR1MAPT | |
| SCHEMBL5807850 | 0.80 | PIK3CD (0.33) | ROCK2MCHR1ELANE | |
| SCHEMBL5759920 | 0.80 | TRPV1 (0.42) | ROCK2MCHR1 | |
| SCHEMBL5761129 | 0.79 | MCHR1 (0.45) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | claimed |
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | disclosed |