Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTR2B | P41595 | 3/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5410501 | 1.00 | HTR2C (0.59) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL5410487 | 0.97 | HTR2C (0.56) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL6499578 | 0.88 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL6500335 | 0.87 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL5419945 | 0.85 | HTR2C (0.77) | HTR2CHTR2AHTR2B | |
| SCHEMBL5847626 | 0.85 | HTR2C (0.77) | HTR2CHTR2AHTR2B | |
| SCHEMBL6756272 | 0.84 | HTR2C (0.61) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL5417225 | 0.82 | HTR2C (0.73) | HTR2CHTR2AHTR2B | |
| SCHEMBL6918350 | 0.82 | HTR2A (0.41) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 | |
| SCHEMBL5407323 | 0.82 | HTR2A (0.41) | HTR2CHTR2AHTR2BCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-20040209864-A1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-10-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209864-A1 | Substituted heterocycle fused gamma-carbolines | HCRTR1, HTR2C, OPRK1 | HTR2C 2/4885HTR2A 30/4885HTR2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.