⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847790 | 1.00 | — | — | |
| SCHEMBL5848681 | 0.93 | — | — | |
| SCHEMBL5848281 | 0.90 | CHRNB2 (0.34) | — | |
| SCHEMBL5848280 | 0.90 | CHRNB2 (0.34) | — | |
| SCHEMBL5848286 | 0.90 | CHRNB2 (0.34) | — | |
| SCHEMBL5847843 | 0.82 | CHRNB2 (0.35) | — | |
| SCHEMBL5847837 | 0.82 | CHRNB2 (0.35) | — | |
| SCHEMBL5847899 | 0.82 | CHRNB2 (0.35) | — | |
| SCHEMBL5848246 | 0.74 | CHRNB2 (0.48) | — | |
| SCHEMBL6821406 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152723-A1 | Pharmaceutical compositions and methods for use | CLARK THOMAS JEFFREY (US) | 2004-08-05 | — | — | US | claimed |
| US-6624167-B1 | Compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can | TARGACEPT, INC. | 2003-09-23 | — | — | US | claimed |
| EP-1305316-A2 | AZABICYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | Targacept, Inc. (US) | 2003-05-02 | — | — | EP | claimed |
| WO-2002012245-A2 | AZABICYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | TARGACEPT, INC. (US) | 2002-02-14 | — | — | WO | claimed |
| US-7022706-B2 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20040152723-A1 | Pharmaceutical compositions and methods for use | CLARK THOMAS JEFFREY (US) | 2004-08-05 | — | — | US | disclosed |
| US-6624167-B1 | Compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can | TARGACEPT, INC. | 2003-09-23 | — | — | US | disclosed |
| EP-1305316-A2 | AZABICYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | Targacept, Inc. (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002012245-A2 | AZABICYCLIC DERIVATIVES AND THEIR THERAPEUTIC USE | TARGACEPT, INC. (US) | 2002-02-14 | — | — | WO | disclosed |