Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759598 | 1.00 | THRA (0.68) | THRATHRBCYP2C9ALDH1A1LMNA | |
| SCHEMBL26230008 | 0.89 | THRA (0.54) | THRATHRBCYP2C9ALDH1A1LMNA | |
| SCHEMBL11075593 | 0.87 | THRA (0.62) | THRATHRBCYP2C9LMNAMAPT | |
| SCHEMBL11075600 | 0.87 | THRA (0.62) | THRATHRBCYP2C9LMNAMAPT | |
| SCHEMBL14192459 | 0.86 | CYP2C9 (0.63) | THRATHRBCYP2C9ALDH1A1LMNA | |
| SCHEMBL9155324 | 0.86 | THRA (0.60) | THRATHRBCYP2C9LMNAMAPT | |
| SCHEMBL9155320 | 0.86 | THRA (0.60) | THRATHRBCYP2C9LMNAMAPT | |
| SCHEMBL9759128 | 0.78 | THRA (0.42) | THRATHRBCYP2C9ALDH1A1LMNA | |
| SCHEMBL9759134 | 0.78 | THRA (0.42) | THRATHRBCYP2C9ALDH1A1LMNA | |
| SCHEMBL4713780 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026021-B2 | Fluorinated heterocycles and their use in liquid-crystal mixtures | MERCK PATENT GMBH (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20050056812-A1 | Fluorinated heterocycles and their use in liquid-crystal mixtures | MERCK PATENT GMBH (DE) | 2005-03-17 | — | — | US | disclosed |
| US-4985583-A | Liquid Crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-01-15 | — | — | US | disclosed |
| EP-0154849-A2 | Cyclohexane derivatives | MERCK PATENT GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050056812-A1 | Fluorinated heterocycles and their use in liquid-crystal mixtures | CHRM1, SCO2, CHRM2 | THRA 922/4885THRB 622/4885CYP2C9 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.