Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819603 | 0.91 | HIF1A (0.50) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL30956698 | 0.91 | HIF1A (0.50) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL30956726 | 0.91 | HIF1A (0.50) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL10875706 | 0.91 | HIF1A (0.50) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL2293713 | 0.87 | HIF1A (0.69) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL2291633 | 0.87 | HIF1A (0.69) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL27711232 | 0.87 | HIF1A (0.69) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| Benzene SCHEMBL27711271 | 0.86 | HIF1A (0.67) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| Benzene SCHEMBL27711278 | 0.86 | HIF1A (0.67) | HIF1ALMNAGALR3ADRB1ADRB3 | |
| SCHEMBL12186420 | 0.86 | HIF1A (0.46) | HIF1ALMNAGALR3ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112605-B2 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences (CN) | 2006-09-26 | — | — | US | disclosed |
| US-20040029951-A1 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | RESEARCH INSTITUTE OF MATERIAL MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; | 2004-02-12 | — | — | US | disclosed |
| CN-1134413-C | Sulfonyl-containing pyrrolidone compound and preparation method and pharmaceutical application thereof | 诺瓦提斯公司 | 2004-01-14 | — | — | CN | disclosed |
| CN-1318541-A | Sulfonyl-containing pyrrolidone compound and preparation method and pharmaceutical application thereof | INST OF PHARMACOLOGY CHINESE A (CN) | 2001-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029951-A1 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | PTGS1, PTGS2, PTGER1 | HIF1A 719/4885LMNA 2751/4885GALR3 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.