Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102476 | 0.94 | HDAC3 (0.75) | SMN1; SMN2ALDH1A1LMNAKMT2AHDAC3 | |
| SCHEMBL13299860 | 0.94 | HDAC3 (0.75) | SMN1; SMN2ALDH1A1LMNAKMT2AHDAC3 | |
| Hydrochloric Acid SCHEMBL3128502 | 0.93 | HDAC3 (0.73) | SMN1; SMN2ALDH1A1LMNAKMT2AHDAC3 | |
| SCHEMBL3188696 | 0.90 | KMT2A (0.71) | SMN1; SMN2ALDH1A1LMNAKMT2AHDAC3 | |
| SCHEMBL8516755 | 0.89 | SMN1; SMN2 (0.90) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL7374849 | 0.88 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL9341104 | 0.85 | KMT2A (0.83) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL31658991 | 0.85 | KMT2A (0.83) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL1428267 | 0.83 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL18912555 | 0.83 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1KMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115741-B2 | 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds | ALEXION PHARMACEUTICALS, INC. | 2006-10-03 | — | — | US | disclosed |
| US-20030153556-A1 | Piperazine and homopiperazine compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2003-08-14 | — | — | US | disclosed |
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |
| US-6020366-A | Butyric acid matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153556-A1 | Piperazine and homopiperazine compounds | HAMP, MPL, F2 | SMN1; SMN2 4536/4885ALDH1A1 3346/4885LMNA 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.