Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728661 | 1.00 | RET (0.55) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL5367197 | 0.84 | MAPT (0.52) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL5727946 | 0.84 | PDPK1 (0.55) | RETFLT3PDPK1GSK3BPDGFRB | |
| SCHEMBL7878729 | 0.84 | LRRK2 (0.58) | RETRPS6KA3PDGFRBLRRK2 | |
| SCHEMBL14519137 | 0.84 | LRRK2 (0.58) | RETRPS6KA3PDGFRBLRRK2 | |
| SCHEMBL5727942 | 0.84 | PDPK1 (0.55) | RETFLT3PDPK1GSK3BPDGFRB | |
| Su-9516 SCHEMBL25386665 | 0.81 | TLK2 (0.61) | RETFLT3PDPK1RPS6KA3GSK3B | |
| Su-9516 SCHEMBL30567582 | 0.81 | TLK2 (0.61) | RETFLT3PDPK1RPS6KA3GSK3B | |
| Su-9516 SCHEMBL19424245 | 0.81 | TLK2 (0.61) | RETFLT3PDPK1RPS6KA3GSK3B | |
| SCHEMBL2998484 | 0.81 | GSK3B (0.65) | RETALKFLT3PDPK1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316635-B1 | USED IN PROPHYLAXIS AND THERAPY OF PROTEIN KINASE RELATED CELLULAR DISORDERS SUCH AS CANCER, DIABETES, AUTOIMMUNE DISORDER, HYPERPROLIFERATION DISORDER, INFLAMMATORY DISORDER, ANGIOGENESIS, RESTENOSIS, FIBROSIS, PSORIASIS, OSTEOARTHRITIS | SUGEN, INC. | 2001-11-13 | — | — | US | claimed |
| US-7105563-B2 | Indolinone derivatives and their use in treating disease-states such as cancer | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-09-12 | — | — | US | disclosed |