Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519137 | 1.00 | LRRK2 (0.58) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5727946 | 0.84 | PDPK1 (0.55) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5367197 | 0.84 | MAPT (0.52) | LRRK2RETPDGFRBRPS6KA3TGM2 | |
| SCHEMBL5727942 | 0.84 | PDPK1 (0.55) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5849994 | 0.84 | RET (0.55) | LRRK2RETPDGFRBRPS6KA3 | |
| SCHEMBL5728661 | 0.84 | RET (0.55) | LRRK2RETPDGFRBRPS6KA3 | |
| Su-9516 SCHEMBL25386665 | 0.81 | TLK2 (0.61) | LRRK2RETPDGFRBRPS6KA3MDM2 | |
| Su-9516 SCHEMBL30567582 | 0.81 | TLK2 (0.61) | LRRK2RETPDGFRBRPS6KA3MDM2 | |
| Su-9516 SCHEMBL19424245 | 0.81 | TLK2 (0.61) | LRRK2RETPDGFRBRPS6KA3MDM2 | |
| SCHEMBL5728250 | 0.81 | GSK3B (0.65) | LRRK2RETPDGFRBRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316635-B1 | USED IN PROPHYLAXIS AND THERAPY OF PROTEIN KINASE RELATED CELLULAR DISORDERS SUCH AS CANCER, DIABETES, AUTOIMMUNE DISORDER, HYPERPROLIFERATION DISORDER, INFLAMMATORY DISORDER, ANGIOGENESIS, RESTENOSIS, FIBROSIS, PSORIASIS, OSTEOARTHRITIS | SUGEN, INC. | 2001-11-13 | — | — | US | claimed |