Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13276251 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL5852681 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL29774561 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL4257034 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL4257039 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL14114325 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL18934346 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| SCHEMBL5851382 | 0.98 | NR4A1 (0.50) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| Hydrochloric Acid SCHEMBL5851417 | 0.97 | NR4A1 (0.49) | NR4A1ALDH1A1PKML3MBTL1MAOA | |
| Bromide SCHEMBL5923769 | 0.95 | NR4A1 (0.47) | NR4A1ALDH1A1PKML3MBTL1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148174-B2 | Non-metallocene catalyst system | CELANESE VENTURES GMBH (DE) | 2006-12-12 | — | — | US | disclosed |
| US-20060135352-A1 | Process for polymerizing olefins with non-metallocene catalysts | CELANESE VENTURES GMBH (DE) | 2006-06-22 | — | — | US | disclosed |
| US-20050037918-A1 | Non-metallocenes, method for the production thereof and use thereof in the polymerization of olefins | CELANESE VENTURES GMBH (DE) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037918-A1 | Non-metallocenes, method for the production thereof and use thereof in the polymerization of olefins | NOTUM, CYP4F12, CYP4F2 | NR4A1 796/4885ALDH1A1 663/4885PKM 414/4885 |
| US-20060135352-A1 | Process for polymerizing olefins with non-metallocene catalysts | NOTUM, CPNE4, WASF2 | NR4A1 219/4885ALDH1A1 1407/4885PKM 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.