Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.30 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2115001 | 0.99 | KMT2A (0.33) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL216447 | 0.99 | KMT2A (0.33) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2119519 | 0.85 | MEN1 (0.33) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2117855 | 0.85 | MEN1 (0.33) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5853731 | 0.82 | HPGD (0.37) | NPSR1SMN1; SMN2LMNAP2RX7GAA | |
| Hydrochloric Acid SCHEMBL5855622 | 0.81 | HPGD (0.39) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5853020 | 0.81 | HPGD (0.39) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5852944 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL2117144 | 0.80 | HDAC8 (0.35) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2117000 | 0.80 | HDAC8 (0.35) | NPSR1SMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2004106394-A1 | COPOLYMERS OF ETHYLENE AND/OR α-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |