Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 10/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858045 | 1.00 | IDO1 (0.45) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL3868450 | 0.93 | IDO1 (0.47) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL3868453 | 0.93 | IDO1 (0.47) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5500650 | 0.89 | ASAH1 (0.46) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5500655 | 0.89 | ASAH1 (0.46) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5495929 | 0.88 | ASAH1 (0.46) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5495926 | 0.88 | ASAH1 (0.46) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5499636 | 0.86 | ASAH1 (0.48) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5499632 | 0.86 | ASAH1 (0.48) | IDO1ALDH1A1MAPTHSD17B10ASAH1 | |
| SCHEMBL5500631 | 0.86 | ASAH1 (0.48) | IDO1ALDH1A1MAPTHSD17B10ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022825-B2 | Polyketides and antibiotics | KOSAN BIOSCIENCES, INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20030096374-A1 | Preparation of ketide ester; obtain benzoxazolone derivative, incubate with polyketide synthase, recover ketide oligomer | ASHLEY GARY (US) | 2003-05-22 | — | — | US | disclosed |
| US-20030092140-A1 | Novel polyketides and antibiotics | ASHLEY GARY (US) | 2003-05-15 | — | — | US | disclosed |
| US-6492562-B1 | INVENTION ALSO RELATES TO NOVEL INTERMEDIATES AND THE RESULTING MODIFIED POLYKETIDES AND ANTIBIOTICS. | KOSAN BIOSCIENCES, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096374-A1 | Preparation of ketide ester; obtain benzoxazolone derivative, incubate with polyketide synthase, recover ketide oligomer | COASY, KARS1, ACOT7 | IDO1 3584/4885ALDH1A1 2800/4885MAPT 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.