⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777733 | 0.81 | — | — | |
| SCHEMBL29036709 | 0.79 | — | — | |
| SCHEMBL5399850 | 0.77 | CTSA (0.39) | — | |
| SCHEMBL776770 | 0.72 | — | — | |
| SCHEMBL778200 | 0.69 | — | — | |
| SCHEMBL22651 | 0.69 | TSHR (0.35) | — | |
| SCHEMBL25644075 | 0.69 | ACHE (0.36) | — | |
| SCHEMBL4136471 | 0.69 | — | — | |
| SCHEMBL28768881 | 0.67 | TSHR (0.32) | — | |
| SCHEMBL4028324 | 0.66 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049432-B2 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20030078414-A1 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. | 2003-04-24 | — | — | US | disclosed |
| US-6486313-B1 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. | 2002-11-26 | — | — | US | disclosed |
| EP-1169329-A4 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS INC (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1169329-A1 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS, INC. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000049032-A1 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS, INC. (US) | 2000-08-24 | — | — | WO | disclosed |