Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563045 | 0.86 | HTT (0.41) | CYP2C19ALDH1A1HPGDHTTLMNA | |
| SCHEMBL404362 | 0.80 | CYP2C19 (0.42) | CYP2C19ALDH1A1HPGDHTTLMNA | |
| SCHEMBL10280055 | 0.79 | CYP2C19 (0.41) | CYP2C19ALDH1A1HPGDADRA2AADRA2B | |
| SCHEMBL855182 | 0.75 | HTR2A (0.39) | HTTTRPV1HTR2AHTR2CHTR2B | |
| SCHEMBL9923777 | 0.75 | C5AR1 (0.32) | HTTMEN1KMT2ATRPV1HTR2A | |
| SCHEMBL14003523 | 0.74 | P2RX3 (0.52) | P2RX3 | |
| SCHEMBL31332312 | 0.73 | CYP2C19 (0.50) | CYP2C19ALDH1A1HPGDHTTLMNA | |
| SCHEMBL21823166 | 0.72 | HTT (0.44) | ALDH1A1HPGDHTTLMNATP53 | |
| SCHEMBL996761 | 0.70 | P2RX3 (0.62) | P2RX3 | |
| SCHEMBL7022728 | 0.70 | HTT (0.35) | HTTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105667-B2 | Fused heterocyclic compounds and use thereof | BRISTOL-MYERS SQUIBB CO. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20030191143-A1 | Fused heterocyclic compounds and use thereof | BRISTOL-MYERS SQUIBB COMPANY | 2003-10-09 | — | — | US | disclosed |
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-05 | — | — | US | disclosed |
| US-20030092908-A1 | Fused heterocyclic inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB COMPANY | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092908-A1 | Fused heterocyclic inhibitors of phosphodiesterase (PDE) 7 | PDE3A, PDE5A, PDE3B | CYP2C19 781/4885ALDH1A1 806/4885HPGD 230/4885 |
| US-20030104974-A1 | Dual inhibitorsof PDE 7 and PDE 4 | PDE4A, PDE4B, PDE7B | CYP2C19 777/4885ALDH1A1 1814/4885HPGD 2653/4885 |
| US-20030191143-A1 | Fused heterocyclic compounds and use thereof | NFATC1, MCL1, BCR | CYP2C19 253/4885ALDH1A1 380/4885HPGD 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.