Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327610 | 0.81 | GABRA5 (0.38) | ESR1SMN1; SMN2TBXAS1MAPTP4HTM | |
| SCHEMBL9554664 | 0.79 | SMN1; SMN2 (0.39) | ESR1SMN1; SMN2LMNATBXAS1HDAC6 | |
| SCHEMBL693477 | 0.78 | FNTA (0.47) | ESR1SMN1; SMN2HDAC6EGLN3 | |
| SCHEMBL10837603 | 0.77 | CYP4F2 (0.43) | SMN1; SMN2LMNAMAPTALDH1A1 | |
| Bromide SCHEMBL28813244 | 0.76 | FNTA (0.46) | ESR1SMN1; SMN2LMNAHDAC6 | |
| SCHEMBL18106170 | 0.74 | SMN1; SMN2 (0.45) | ESR1SMN1; SMN2LMNATBXAS1HDAC6 | |
| SCHEMBL5319750 | 0.73 | MEN1 (0.41) | ESR1SMN1; SMN2LMNAHDAC6MAPT | |
| Hydrochloric Acid SCHEMBL9659850 | 0.71 | TLR8 (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL10845166 | 0.70 | HSD17B10 (0.41) | LMNAHDAC6MAPTKEAP1P4HTM | |
| SCHEMBL10412214 | 0.70 | HSP90AA1 (0.43) | SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060818-B2 | Synthesis of macrocyclic tetraamido compounds and new metal insertion process | CARNEGIE MELLON UNIVERSITY (US) | 2006-06-13 | — | — | US | disclosed |