Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.47 |
| ▸ | PDE1A | P54750 | 4/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859626 | 0.98 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL5860610 | 0.90 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL5859742 | 0.89 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL5884365 | 0.89 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL5884434 | 0.88 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5883903 | 0.87 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5860677 | 0.87 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CADORA2B | |
| SCHEMBL5884355 | 0.86 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL5884416 | 0.85 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CADORA2A | |
| SCHEMBL5883869 | 0.85 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074790-B2 | 5-ethylimidarotriazones | BAYER HEALTHCARE AG (DE) | 2006-07-11 | — | — | US | disclosed |
| US-20060040942-A1 | 5-ethylimidarotriazones | BAYER HEALTHCARE AG (DE) | 2006-02-23 | — | — | US | disclosed |
| EP-1506198-A1 | 5-ETHYLIMIDAROTRIAZONES | Bayer HealthCare AG (DE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097645-A1 | 5-ETHYLIMIDAROTRIAZONES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040942-A1 | 5-ethylimidarotriazones | IL5, EPX, NFATC1 | PDE5A 378/4885PDE1A 834/4885PDE1B 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.