Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247 | 0.88 | — | — | |
| Potassium SCHEMBL4796489 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL27664674 | 0.86 | — | — | |
| SCHEMBL29068306 | 0.86 | — | — | |
| Ammonia Solution, Strong SCHEMBL28019455 | 0.86 | — | — | |
| Calcium SCHEMBL31006618 | 0.86 | — | — | |
| SCHEMBL9705788 | 0.82 | ALDH1A1 (0.39) | TSHRALDH1A1GPR35GRIN2DGRIN3B | |
| Acetic Acid SCHEMBL27711821 | 0.81 | MAPK1 (0.32) | ALDH1A1HTTMAPK1 | |
| SCHEMBL28178662 | 0.75 | — | — | |
| Morpholine SCHEMBL27664649 | 0.71 | POLB (0.33) | KDM4EPOLBCYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39355-E1 | Preparation of human IGF via recombinant DNA technology | GENETECH, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| US-6465235-B1 | OXIDATION, HEAT AND ALKALI RESISTANCE | GENENCO INTERNATIONAL, INC. | 2002-10-15 | — | — | US | disclosed |
| US-6331414-B1 | GENERATING INSULIN LIKE GROWTH FACTOR; CONSTRUCT EXPRESSION VECTOR, TRANSFORM PROKARYOTIC CELL, CULTURE CELLS, RECOVER INSULIN LIKE GROWTH FACTOR | GENENTECH, INC. | 2001-12-18 | — | — | US | disclosed |
| US-6331609-B1 | FUSION PROTEIN; FOR USE IN TREATMENT OF SOMATOTROPIN DEFECTS | GENENTECH, INC. | 2001-12-18 | — | — | US | disclosed |
| EP-0130756-B2 | Procaryotic carbonyl hydrolases, methods, DNA, vectors and transformed hosts for producing them, and detergent compositions containing them | GENENCOR INT (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5972682-A | Enzymatically active modified subtilisins | GENENCOR INTERNATIONAL, INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5955340-A | DNA CODING POLYPEPTIDE WITH ALTERED HEAT OXIDATION AND ALKALI RESISTANCE, SUBSTRATE SPECIFICITY AND ENZYME KINETICS | GENENCOR INTERNATIONAL, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| US-5939315-A | FUSION DNA THAT ENCODE PREMATURE SUBTILISIN PROTEIN AND OTHER POLYPEPTIDES; FOR PRODUCING POLYPEPTIDES FREE CELL HOST CELL MEMBRANES | ADAMS ROBIN MARGARET (US) | 1999-08-17 | — | — | US | disclosed |
| US-5801038-A | DETERGENTS | GENENCOR INTERNATIONAL INC. (US) | 1998-09-01 | — | — | US | disclosed |
| US-5763257-A | Modified subtilisins having amino acid alterations | GENENCOR INTERNATIONAL, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0246678-B1 | BACILLUS INCAPABLE OF EXCRETING SUBTILISIN OR NEUTRAL PROTEASE | GENENCOR INTERNATIONAL, INC. (US) | 1993-04-28 | — | — | EP | disclosed |
| EP-0128733-B1 | HUMAN INSULIN-LIKE GROWTH FACTOR (IGF) PRODUCED FROM A RECOMBINANT HOST, PROCESS, EXPRESSION VECTOR AND RECOMBINANT HOST THEREFOR, AND IGF-CONTAINING PHARMACEUTICAL COMPOSITION | GENENTECH, INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| US-5021550-A | Method for preventing deletion sequences in solid phase synthesis | THOMAS JEFFERSON UNIVERSITY (US) | 1991-06-04 | — | — | US | disclosed |
| US-4940661-A | Metallothionein transcription control sequences and use thereof | GENENTECH, INC. (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0357157-A2 | Procaryotic carbonyl hydrolases and mutants thereof, and methods for producing and using them | GENENCOR INTERNATIONAL, INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4760025-A | Modified enzymes and methods for making same | GENENCOR, INC. (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0247647-A1 | DNA mutagenesis method | GENENTECH, INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| EP-0246678-A1 | Bacillus incapable of excreting subtilisin or neutral protease | GENENCOR INTERNATIONAL, INC. (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0130756-A1 | Procaryotic carbonyl hydrolases, methods, DNA, vectors and transformed hosts for producing them, and detergent compositions containing them | GENENCOR INTERNATIONAL, INC. (US) | 1985-01-09 | — | — | EP | disclosed |
| EP-0128733-A1 | Human insulin-like growth factor (IGF) produced from a recombinant host, process, expression vector and recombinant host therefor, and IGF-containing pharmaceutical composition | GENENTECH, INC. (US) | 1984-12-19 | — | — | EP | disclosed |