Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586073 | 1.00 | BLM (0.65) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL4623745 | 0.87 | BLM (0.47) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL4623739 | 0.87 | BLM (0.47) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL31563007 | 0.84 | GRM2 (0.58) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL6532919 | 0.83 | KDM4E (0.59) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL29053361 | 0.83 | CTBP2 (0.46) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL122296 | 0.82 | BLM (0.72) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL122295 | 0.82 | BLM (0.72) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL202327 | 0.82 | BLM (0.72) | BLMCYP1A2CYP3A4ALOX15KDM4E | |
| SCHEMBL6339842 | 0.82 | BLM (0.58) | BLMCYP1A2CYP3A4ALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | claimed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | claimed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1992001667-A1 | RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-02-06 | — | — | WO | claimed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-4230883-A | REACTION OF CORRESPONDING AMINO ACID WITH HCL OR HBR IN THE ABSENCE OF A SOLVENT | MERCK & CO., INC. (US) | 1980-10-28 | — | — | US | claimed |
| US-20240124496-A1 | BORONIC ACID COMPOUND AND METHOD FOR PRODUCING SAME | OSAKA UNIVERSITY (JP) | 2024-04-18 | — | — | US | disclosed |
| WO-2024063095-A1 | RADIOLABELED TYROSINE DERIVATIVE AND APPLICATION THEREOF | 国立大学法人大阪大学 | 2024-03-28 | — | — | WO | disclosed |
| CN-117561267-A | Boric acid compound and method for producing same | 国立大学法人大阪大学 | 2024-02-13 | — | — | CN | disclosed |
| EP-4317165-A1 | BORONIC ACID COMPOUND AND METHOD FOR PRODUCING SAME | OSAKA UNIVERSITY (JP) | 2024-02-07 | — | — | EP | disclosed |
| CN-105073757-B | Dyeing process using a hair-dyeing precursor obtained from an iridoid, composition, precursor and device comprising such a precursor | 莱雅公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-2978749-A1 | OPTIONALLY PROTECTED IRIDOID-DERIVED COMPOUNDS, COMPOSITION INCLUDING SAME, USE AS A DYE FOR KERATIN FIBRES AND DEVICES | L'Oréal (FR) | 2016-02-03 | — | — | EP | disclosed |
| US-4483870-A | α-Difluoromethyl amino acids and hypertension treating compositions thereof | MERCK & CO., INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4389415-A | ALPHA-METHYL-P-TYROSINE, HYDRAZINO PHENYLPROPIONIC ACID | MERCK & CO., INC. (US) | 1983-06-21 | — | — | US | disclosed |
| EP-0007600-B1 | ALPHA-DIFLUOROMETHYL AMINO ACIDS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1983-05-11 | — | — | EP | disclosed |
| EP-0007600-A1 | Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1980-02-06 | — | — | EP | disclosed |
| EP-0003353-A1 | A pharmaceutical composition for oral administration for treating hypertension | MERCK & CO. INC. (US) | 1979-08-08 | — | — | EP | disclosed |
| US-4117161-A | METHOD OF PHARMACOLOGICALLY TREATING DRUG ADDICTION WITH ALPHA-METHYL-PARA-TYROSINE | POZUELO JOSE | 1978-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124496-A1 | BORONIC ACID COMPOUND AND METHOD FOR PRODUCING SAME | ABL1, BTD, BMX | BLM 2083/4885CYP1A2 704/4885CYP3A4 605/4885 |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | GLS, APEH, GGH | BLM 4877/4885CYP1A2 1710/4885CYP3A4 1387/4885 |
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | GLS, DBH, APEH | BLM 4881/4885CYP1A2 2289/4885CYP3A4 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.