Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.50 |
| ▸ | PPARD | Q03181 | 8/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5860930 | 0.88 | PPARA (0.41) | PPARAPPARDPTGDR2PPARG | |
| SCHEMBL5861817 | 0.86 | PPARD (0.49) | PPARAPPARDPTGDR2PPARG | |
| SCHEMBL5860856 | 0.85 | PPARD (0.48) | PPARAPPARDPTGDR2 | |
| SCHEMBL5862831 | 0.84 | PPARA (0.41) | PPARAPPARDPTGDR2PPARGFFAR1 | |
| SCHEMBL5862803 | 0.83 | PPARD (0.61) | PPARAPPARDPPARGFFAR1FFAR4 | |
| SCHEMBL5861952 | 0.83 | PPARD (0.46) | PPARAPPARDPPARG | |
| SCHEMBL5861885 | 0.81 | PPARD (0.49) | PPARAPPARDPTGDR2PPARG | |
| SCHEMBL6166217 | 0.80 | PPARD (0.44) | PPARAPPARDPTGDR2PPARG | |
| SCHEMBL5862820 | 0.80 | PPARD (0.48) | PPARAPPARDPPARG | |
| SCHEMBL5861827 | 0.79 | PPARD (0.48) | PPARAPPARDPTGDR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091237-B2 | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1392674-B1 | FURAN AND THIOPHENE DERIVATIVES THAT ACTIVATE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | SMITHKLINE BEECHAM CORP (US) | 2005-08-10 | — | — | EP | disclosed |
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | GLAXO GROUP LIMITED (GB) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157890-A1 | Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors | PPARG, PPARD, PPARA | PPARA 3/4885PPARD 2/4885PTGDR2 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.