Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863196 | 1.00 | KCNQ2 (0.60) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863200 | 1.00 | KCNQ2 (0.60) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863060 | 0.94 | KCNQ2 (0.58) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863063 | 0.94 | KCNQ2 (0.58) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863062 | 0.94 | KCNQ2 (0.58) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863188 | 0.92 | KCNQ2 (0.61) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863194 | 0.92 | KCNQ2 (0.61) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863184 | 0.92 | KCNQ2 (0.61) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863130 | 0.92 | KCNQ3 (0.71) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL5863134 | 0.92 | KCNQ3 (0.71) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087609-B2 | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | claimed |
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | claimed |
| EP-1572112-A4 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2006-12-06 | — | — | EP | disclosed |
| US-7087609-B2 | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1572112-A2 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004047745-A2 | 3-(PYRIDINYL-PIPERAZIN-1-YL)-PHENYLETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | KCNQ3, KCNQ1, KCNQ2 | KCNQ2 3/4885CYP3A4 783/4885KCNQ3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.